Immune activation effects of Eurotium cristatum on T cells through NF-κB signaling pathways in humans

SnapShot: NF-κB Signaling Pathways

S100A9 aggravates bleomycin-induced dermal fibrosis in mice via activation of ERK1/2 MAPK and NF-κB pathways

Objective(s): This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of scleroderma. Materials and Methods: The content of S100A9 in the skin tissues of mice with scleroderma was determined. Different concentrations of bleomycin (BLM) and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes i...

simultaneous analysis of wnt and nf-κb signaling pathways in doxorubicin sensitive and methotrexate resistant plc/ prf/5 cells

background: multi-drug resistance (mdr) is a controversial issue in traditional chemotherapy of aggressive cancers, including hepatocellular carcinoma. the major cause of mdr is suggested to be the aberrant activation of the main signaling pathways such as wnt and nuclear factor kappa-light-chain-enhancer of activated b cells (nf- κb) which have key roles in the maintenance of cancer stem cells...

Hyperglycemia- Induced NF-κB Activation Increases microRNA-146a Expression in Human Umbilical Vein Endothelial Cells

Background & objectives: Nuclear Factor kappa B (NF-κB), a master switch transcription factor, plays a critical role in the progression and development of hyperglycemia-induced microangiopathy. Hyperglycemia activates NF-κB, and subsequently increases pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β leading to development of inflammation. Some new studies have revealed the involvement o...

Tacrolimus Inhibits NF-κB Activation in Peripheral Human T Cells

The calcineurin inhibitor, tacrolimus (TAC), inhibits the protein phosphatase activity of calcineurin, leading to suppression of the nuclear translocation of NFAT and inhibition of T cell activation. Apart from NFAT also the transcription factor NF-κB plays a key functional role in T cell activation. Therefore, blockade of the NF-κB activation cascade by immunosuppressive drugs prevents immune ...